Manufacturer: Rx Merck Research Laboratories
Uses: Cox-2 inhibitor designed to relieve the signs and symptoms of osteoarthritis and rheumatoid arthritis in adults.
If you have taken or are taking Vioxx,
please contact us immediately.
ALERT!
Update as of September 30th, 2004 from MedWatch - The FDA Safety Information and Adverse Event Reporting Program

Vioxx
Merck & Co., Inc. announced a voluntary withdrawal of Vioxx (rofecoxib) from the U.S. and worldwide market due to safety concerns of an increased risk of cardiovascular events (including heart attack and stroke) in patients on Vioxx. Vioxx is a prescription COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) that was approved by FDA in May 1999 for the relief of the signs and symptoms of osteoarthritis, for the management of acute pain in adults, and for the treatment of menstrual symptoms, and was later approved for the relief of the signs and symptoms of rheumatoid arthritis in adults and children.
Read the 2004 MedWatch safety summary, including links to the Public Health Advisory, press release, and Q&As, at:
http://www.fda.gov/medwatch/SAFETY/2004/safety04.htm#vioxx
Vioxx (Rofecoxib) and Celebrex are drugs that are prescribed by physicians
to relieve pain, including pain from arthritis, pain from menstrual
cycles, and other general sources of acute pain.
Recently, an advisory panel of the Food and Drug Administration
recommended to the FDA that Vioxx's label should warn physicians
and patients of a possible increased risk of heart attacks or other
adverse cardiovascular events. In addition, an article recently
appeared in the Journal of the American Medical Association that
raises "a cautionary flag" about the risk of heart attacks
or other adverse cardiovascular events associated with the usage
of COX-2 inhibitors such as Vioxx and Celebrex. COX-2 inhibitors
such as Vioxx and Celebrex have been shown to increase blood pressure
in patients, which in turn can increase a patient's risk of
stroke, heart attack, and/or other adverse cardiovascular events.
In addition, the makers of Vioxx and Celebrex have received several
reports of possibly kidney dysfunction and/or kidney failure associated
with the usage of these drugs.
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- Increased risk of heart attack
- Increased risk of stroke
- Increased blood pressure
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